Characterization and correction of Cdkl5 nuclear function in human CDD neurons during maturation

CDKL5CDKL5 Pilot Grant Programme
Written by Million Dollar Bike Ride

Awardee: Simone DiGiovanni, MD, PhD

Institution: Imperial College London

Award Amount: $149,277

Million Dollar Bike Ride
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Nucleic acid binding by ZC4H2
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Elucidate the neural mechanisms underlying sleep disturbances and the relation between seizures and sleep-wake cycle in CDKL5 deficiency disorder (CDD)