Awardee: Takuya Harada
Institution: National Hospital Organization Kyushu Medical Center
Grant Amount: $63,270.00
Funding Period: February 1, 2024 - January 31, 2025
Summary:
We have established a patient-derived xenograft (PDX) mouse model of idiopathic multicentric Castleman disease (iMCD). Through preliminary research on these mice, we have discovered the contribution of specific immune cells called peripheral helper T (Tph) cells to the pathophysiology of iMCD. By examining the dynamics of these cells in both patients and the mouse model, we are studying further research to understanding the pathophysiology of iMCD.