Evaluation of a therapeutic potential of disulfiram for its repositioning against encephalopathies caused by GNAO1 mutations

JumpstartGrant Assistance ProgramBow Foundation2025
Written By Million Dollar Bike Ride

Awardee: Vladimir Katanaev

Institution: University of Geneva, Faculty of Medicine

Grant Amount: $100,000

Funding Period: January 1, 2026 - December 31, 2027

Summary: This project investigates disulfiram, a repositioned FDA-approved drug, for GNAO1 encephalopathies using biochemical, cellular, and animal model studies to evaluate its efficacy and safety in treating movement disorders and seizures.

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DEVELOPMENT OF PHARMACOLOGICAL CHAPERONE FOR FUNCTIONAL RESCUE OF GalphaO MUTATIONS INVOLVED IN ENCEPHALOPATHY AND MOVEMENT DISORDERS.