Pilot clinical trial to assess efficacy of Caffeine Citrate for controlling GNAO1-related dyskinetic crises

JumpstartGrant Assistance ProgramBow Foundation2025
Written By Million Dollar Bike Ride

Awardee: Serena Galosi

Institution: Sapienza University, Rome

Grant Amount: $100,000

Funding Period: September 1, 2025 - August 31, 2026

Summary: A collaborative team of GNAO1 researchers, investigating caffeine citrate’s ability to control GNAO1-related dyskinetic crises, this study combines preclinical research in animal models with a phase 2 clinical trial to provide scientific evidence for caffeine citrate as a first-line treatment option.

Million Dollar Bike Ride
Previous

DEVELOPMENT OF PHARMACOLOGICAL CHAPERONE FOR FUNCTIONAL RESCUE OF GalphaO MUTATIONS INVOLVED IN ENCEPHALOPATHY AND MOVEMENT DISORDERS.
Next

GNAO1-related epilepsy: genotype-phenotype correlations